Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.

Guicciardi, Maria Eugenia

Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. [electronic resource] - PloS one 2014 - e92124 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0092124 doi


Apoptosis--drug effects
Baculoviral IAP Repeat-Containing 3 Protein
Biomimetic Materials--pharmacology
Cell Line, Tumor
Hepatocytes--cytology
Humans
Inhibitor of Apoptosis Proteins--metabolism
Intracellular Membranes--drug effects
Liver--drug effects
Lysosomes--drug effects
Mitochondrial Proteins--metabolism
Permeability--drug effects
Proteasome Endopeptidase Complex--metabolism
Protein Processing, Post-Translational--drug effects
Proteolysis--drug effects
Signal Transduction--drug effects
TNF-Related Apoptosis-Inducing Ligand--pharmacology
Ubiquitin-Protein Ligases
Ubiquitination--drug effects
Vesicular Transport Proteins--metabolism