Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers.

Chitikova, Zhanna V

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers. [electronic resource] - Cell cycle (Georgetown, Tex.) 2014 - 1424-39 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1551-4005

10.4161/cc.28402 doi


Adenovirus E1A Proteins--genetics
Adenovirus E1B Proteins--genetics
Apoptosis--physiology
Autophagy
Biomarkers--metabolism
Cell Line, Transformed
Cell Proliferation
Cellular Senescence--physiology
DNA Damage
DNA Repair
DNA Replication
Down-Regulation
G2 Phase Cell Cycle Checkpoints
Humans
Nanog Homeobox Protein
Octamer Transcription Factor-3--metabolism
Stem Cells--metabolism
TOR Serine-Threonine Kinases--genetics
Transcription Factors--metabolism