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TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI.

Komar-Stossel, Chani

TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI. [electronic resource] - PloS one 2014 - e90224 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 1932-6203

Standard No.: 10.1371/journal.pone.0090224 doi

Subjects--Topical Terms:
Animals
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cimetidine--administration & dosage
Cyclophosphamide--administration & dosage
Deoxycytidine--administration & dosage
Diclofenac--administration & dosage
Drug Administration Schedule
Drug Combinations
Drug Synergism
Gene Amplification
Humans
Immunohistochemistry
Magnetic Resonance Imaging--methods
Male
Mice, Inbred NOD
Mice, SCID
N-Myc Proto-Oncogene Protein
Neovascularization, Pathologic--drug therapy
Neuroblastoma--blood supply
Nuclear Proteins--genetics
Oncogene Proteins--genetics
Platelet Endothelial Cell Adhesion Molecule-1--metabolism
Sulfasalazine--administration & dosage
Treatment Outcome
Tretinoin--administration & dosage
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Gemcitabine