Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.

Sager, J E

Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4. [electronic resource] - Clinical pharmacology and therapeutics Jun 2014 - 653-62 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1532-6535

10.1038/clpt.2014.50 doi


Adult
Antidepressive Agents, Second-Generation--administration & dosage
Area Under Curve
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biotransformation
Computer Simulation
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6--metabolism
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A--metabolism
Cytochrome P-450 CYP3A Inhibitors
Dextromethorphan--pharmacokinetics
Drug Interactions
Female
Fluoxetine--administration & dosage
Half-Life
Hepatocytes--drug effects
Humans
Lovastatin--pharmacokinetics
Male
Midazolam--pharmacokinetics
Models, Statistical
Omeprazole--pharmacokinetics
Stereoisomerism