Validation of an LC-MS/MS method for the quantitative determination of the orexin receptor antagonist almorexant and its four primary metabolites in human plasma.

Wagner-Redeker, Winfried

Validation of an LC-MS/MS method for the quantitative determination of the orexin receptor antagonist almorexant and its four primary metabolites in human plasma. [electronic resource] - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Mar 2014 - 96-103 p. digital

Publication Type: Journal Article

1873-376X

10.1016/j.jchromb.2014.01.033 doi


Acetamides--blood
Chromatography, Liquid--methods
Drug Stability
Humans
Isoquinolines--blood
Linear Models
Orexin Receptors--agonists
Reproducibility of Results
Sensitivity and Specificity
Tandem Mass Spectrometry--methods