Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein.

Gomez, Ingrid

Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. [electronic resource] - PloS one 2014 - e88021 p. digital

Publication Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0088021 doi


Aged
Collagen--metabolism
Dinoprostone--metabolism
Female
Humans
Hydroxyprostaglandin Dehydrogenases--metabolism
Intramolecular Oxidoreductases--metabolism
Male
Matrix Metalloproteinase 1--metabolism
Matrix Metalloproteinase 2--metabolism
Middle Aged
Prostaglandin-E Synthases
RNA, Messenger--metabolism
Receptors, Prostaglandin E, EP4 Subtype--antagonists & inhibitors
Saphenous Vein--metabolism
Tissue Inhibitor of Metalloproteinase-1--metabolism
Tissue Inhibitor of Metalloproteinase-2--metabolism
Varicose Veins--metabolism