The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor.

Liu, Tian-zhu

The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor. [electronic resource] - The international journal of biochemistry & cell biology Apr 2014 - 8-16 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-5875

10.1016/j.biocel.2014.01.007 doi


Acid Phosphatase
Adenosine--biosynthesis
Adenosine A2 Receptor Antagonists--pharmacology
Animals
Basic Helix-Loop-Helix Transcription Factors--genetics
Blotting, Western
Cell Hypoxia
Cell Line, Tumor
Cell Proliferation--drug effects
Cells, Cultured
Extracellular Signal-Regulated MAP Kinases--metabolism
Female
Glioblastoma--genetics
Humans
Male
Neoplastic Stem Cells--drug effects
Phosphorylation
Protein Tyrosine Phosphatases--genetics
Proto-Oncogene Proteins c-akt--metabolism
RNA Interference
Rats
Rats, Nude
Receptor, Adenosine A2B--genetics
Tumor Cells, Cultured
Xanthines--pharmacology
Xenograft Model Antitumor Assays