Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia.

Baig, Nisar A

Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Feb 2014 - 1620-9 p. digital

Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1550-6606

10.4049/jimmunol.1302954 doi


Adult
Aged
Aged, 80 and over
Alemtuzumab
Antibodies, Monoclonal--blood
Antibodies, Monoclonal, Humanized--therapeutic use
Antigens, CD--biosynthesis
Antigens, CD20--biosynthesis
Antigens, Neoplasm--biosynthesis
Antineoplastic Agents--therapeutic use
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
B-Lymphocytes--cytology
CD52 Antigen
Complement System Proteins--metabolism
Cyclophosphamide--therapeutic use
Cytotoxicity, Immunologic--immunology
Drug Resistance, Neoplasm
Female
Glycoproteins--biosynthesis
Humans
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Lymphocyte Count
Male
Middle Aged
Pentostatin--therapeutic use
Treatment Outcome