Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo.

Lanitis, Evripidis

Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo. [electronic resource] - Cancer immunology research Jul 2013 - 43-53 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2326-6074

10.1158/2326-6066.CIR-13-0008 doi


Animals
Cell Line, Tumor
Chimerism
Female
Humans
Immunotherapy, Adoptive--methods
Mesothelin
Mice
Mice, Inbred NOD
Mice, SCID
Ovarian Neoplasms--immunology
Receptors, Antigen, T-Cell--immunology
Recombinant Fusion Proteins--immunology
Signal Transduction
T-Lymphocytes--immunology
Xenograft Model Antitumor Assays