A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.

Hoffmann, Gesine

A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. [electronic resource] - The Journal of biological chemistry Feb 2014 - 5208-16 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M113.487736 doi


Acetylation--drug effects
Apoptosis--drug effects
Carcinoma, Non-Small-Cell Lung--drug therapy
Drug Screening Assays, Antitumor
Etoposide--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Histone Deacetylase Inhibitors--chemistry
Humans
Inhibitory Concentration 50
Lung Neoplasms--drug therapy
Neoplasm Proteins--genetics
Sirtuin 2--antagonists & inhibitors
Tumor Suppressor Protein p53--metabolism