Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex.

Wang, Yuanzhong

Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. [electronic resource] - The Journal of biological chemistry Feb 2014 - 4815-26 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M113.518480 doi


3-Phosphoinositide-Dependent Protein Kinases--metabolism
Amino Acid Motifs
Animals
Benzoquinones--pharmacology
Cell Cycle Proteins--metabolism
Cell Line, Tumor
Chaperonins--metabolism
Chromatography, Liquid
Drug Resistance, Neoplasm--drug effects
Enzyme Activation--drug effects
Enzyme Stability--drug effects
Estrogens--pharmacology
HSP90 Heat-Shock Proteins--metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Lactams, Macrocyclic--pharmacology
Mass Spectrometry
Mice
Phosphorylation--drug effects
Proteasome Endopeptidase Complex--metabolism
Protein Binding--drug effects
Protein Interaction Mapping
Protein Serine-Threonine Kinases--chemistry
Protein Structure, Tertiary
Proteolysis--drug effects
Structure-Activity Relationship
Ubiquitin-Protein Ligases--metabolism
Ubiquitination--drug effects