Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy.

Ma, Jiacheng

Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy. [electronic resource] - The Journal of pharmacology and experimental therapeutics Feb 2014 - 281-92 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1521-0103

10.1124/jpet.113.210435 doi


Animals
Cells, Cultured
Diabetes Mellitus, Type 1--complications
Diabetes Mellitus, Type 2--complications
Diabetic Neuropathies--prevention & control
Dose-Response Relationship, Drug
Female
Ganglia, Spinal--drug effects
HSP70 Heat-Shock Proteins--genetics
Hypoglycemic Agents--administration & dosage
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mitochondria--drug effects
Mitochondrial Dynamics--drug effects
Neuritis--prevention & control
Neurons--drug effects
Neuroprotective Agents--administration & dosage
Novobiocin--administration & dosage
Oxidative Phosphorylation--drug effects
Sensory Receptor Cells--drug effects