α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway.

Saraswati, Sarita

α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway. [electronic resource] - Molecular cancer Nov 2013 - 147 p. digital

Publication Type: Journal Article; Retracted Publication

1476-4598

10.1186/1476-4598-12-147 doi


Angiogenesis Inhibitors--pharmacology
Animals
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Gene Expression Regulation, Neoplastic
Human Umbilical Vein Endothelial Cells
Humans
Male
Mice
Mice, Nude
Models, Molecular
Molecular Docking Simulation
Molecular Targeted Therapy
Neovascularization, Pathologic--drug therapy
Polycyclic Sesquiterpenes
Prostate--metabolism
Prostatic Neoplasms--drug therapy
Proto-Oncogene Proteins c-akt--genetics
Rats
Sesquiterpenes--pharmacology
Signal Transduction--drug effects
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors
Xenograft Model Antitumor Assays