Synthesis of hydrophilic intra-articular microspheres conjugated to ibuprofen and evaluation of anti-inflammatory activity on articular explants.

Bédouet, Laurent

Synthesis of hydrophilic intra-articular microspheres conjugated to ibuprofen and evaluation of anti-inflammatory activity on articular explants. [electronic resource] - International journal of pharmaceutics Jan 2014 - 51-61 p. digital

Publication Type: Journal Article

1873-3476

10.1016/j.ijpharm.2013.11.004 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--administration & dosage
Cartilage, Articular--drug effects
Chromatography, High Pressure Liquid
Cyclooxygenase Inhibitors--pharmacology
Delayed-Action Preparations
Dialysis
Dinoprostone--metabolism
Hydrolysis
Ibuprofen--administration & dosage
Injections, Intra-Articular
L-Lactate Dehydrogenase--metabolism
Lactic Acid
Lipopolysaccharides--pharmacology
Magnetic Resonance Spectroscopy
Microspheres
Organ Culture Techniques
Particle Size
Polyethylene Glycols
Polyglycolic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Prostaglandin-Endoperoxide Synthases--metabolism
Sheep
Synovial Membrane--drug effects