Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux.
McCommis, Kyle S
Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. [electronic resource] - Journal of the American Heart Association Nov 2013 - e000355 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2047-9980
10.1161/JAHA.113.000355 doi
Adrenergic alpha-Agonists--pharmacology
Animals
Animals, Newborn
Cardiomegaly--chemically induced
Cell Death
Cells, Cultured
Dehydroepiandrosterone--pharmacology
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Female
Glucosephosphate Dehydrogenase--antagonists & inhibitors
Hexokinase--genetics
Isoproterenol
Male
Mice
Mice, Transgenic
Myocytes, Cardiac--drug effects
Oxidative Stress
Pentose Phosphate Pathway--drug effects
Phenylephrine--pharmacology
RNA Interference
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species--metabolism
Time Factors
Transfection
Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. [electronic resource] - Journal of the American Heart Association Nov 2013 - e000355 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2047-9980
10.1161/JAHA.113.000355 doi
Adrenergic alpha-Agonists--pharmacology
Animals
Animals, Newborn
Cardiomegaly--chemically induced
Cell Death
Cells, Cultured
Dehydroepiandrosterone--pharmacology
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Female
Glucosephosphate Dehydrogenase--antagonists & inhibitors
Hexokinase--genetics
Isoproterenol
Male
Mice
Mice, Transgenic
Myocytes, Cardiac--drug effects
Oxidative Stress
Pentose Phosphate Pathway--drug effects
Phenylephrine--pharmacology
RNA Interference
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species--metabolism
Time Factors
Transfection