CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.

Chaudhuri, Leena

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo. [electronic resource] - Haematologica Apr 2014 - 688-96 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1592-8721

10.3324/haematol.2013.093187 doi


Apoptosis--drug effects
Ataxia Telangiectasia Mutated Proteins--antagonists & inhibitors
Cell Cycle Proteins--antagonists & inhibitors
Cell Line, Tumor
Checkpoint Kinase 1
Dose-Response Relationship, Drug
Drug Synergism
Gene Expression Profiling
Gene Silencing
Humans
Leukemia, Myeloid, Acute--drug therapy
Nuclear Proteins--antagonists & inhibitors
Protein Kinase Inhibitors--pharmacology
Protein Kinases--genetics
Protein-Tyrosine Kinases--antagonists & inhibitors
Pyrazoles--pharmacology
Pyrimidines--pharmacology
Pyrimidinones
RNA Interference
RNA, Small Interfering--genetics
Signal Transduction
Tumor Stem Cell Assay