Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor.
Kwak, Eun-Young
Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor. [electronic resource] - Xenobiotica; the fate of foreign compounds in biological systems May 2014 - 465-71 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1366-5928
10.3109/00498254.2013.847218 doi
Acetates--metabolism
Animals
Benzimidazoles--metabolism
Blood Proteins--metabolism
Caco-2 Cells--drug effects
Diacylglycerol O-Acyltransferase--antagonists & inhibitors
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacokinetics
Humans
Inactivation, Metabolic
Intestinal Absorption
Male
Microsomes, Liver--drug effects
Permeability
Rats
Rats, Sprague-Dawley
Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor. [electronic resource] - Xenobiotica; the fate of foreign compounds in biological systems May 2014 - 465-71 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1366-5928
10.3109/00498254.2013.847218 doi
Acetates--metabolism
Animals
Benzimidazoles--metabolism
Blood Proteins--metabolism
Caco-2 Cells--drug effects
Diacylglycerol O-Acyltransferase--antagonists & inhibitors
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacokinetics
Humans
Inactivation, Metabolic
Intestinal Absorption
Male
Microsomes, Liver--drug effects
Permeability
Rats
Rats, Sprague-Dawley