Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.

Parihar, Suraj P

Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation. [electronic resource] - The Journal of infectious diseases Mar 2014 - 754-63 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1537-6613

10.1093/infdis/jit550 doi


Animals
Autophagy--drug effects
Cholesterol--metabolism
Drug Resistance, Bacterial--physiology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Leukocytes, Mononuclear--drug effects
Macrophages--drug effects
Mice
Mice, Inbred C57BL
Mycobacterium tuberculosis--drug effects
Phagosomes--drug effects
Tuberculosis--drug therapy