The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.

Przanowski, Piotr

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia. [electronic resource] - Journal of molecular medicine (Berlin, Germany) Mar 2014 - 239-54 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-1440

10.1007/s00109-013-1090-5 doi


Animals
Cells, Cultured
Chromatin Immunoprecipitation
Cytokines--metabolism
Gene Expression Regulation--drug effects
Gene Silencing--drug effects
Histones--metabolism
Inflammation--genetics
Jumonji Domain-Containing Histone Demethylases--metabolism
Lipopolysaccharides--pharmacology
Lysine--metabolism
Methylation--drug effects
Microglia--metabolism
Phosphorylation--drug effects
Polymerase Chain Reaction
Promoter Regions, Genetic--genetics
Rats
Rats, Wistar
STAT1 Transcription Factor--metabolism
STAT3 Transcription Factor--metabolism