Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
Kester, Robert F
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. [electronic resource] - Journal of medicinal chemistry Oct 2013 - 7788-803 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm400732v doi
Alanine--analogs & derivatives
Animals
Apoptosis--drug effects
Benzodiazepinones--chemical synthesis
Blotting, Western
Caspase 3--metabolism
Caspase 7--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Crystallography, X-Ray
Female
Heterocyclic Compounds--chemical synthesis
Humans
Inhibitor of Apoptosis Proteins--antagonists & inhibitors
Mice
Mice, Nude
Models, Chemical
Models, Molecular
Molecular Structure
Protein Structure, Tertiary
Ubiquitin-Protein Ligases
X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors
Xenograft Model Antitumor Assays
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. [electronic resource] - Journal of medicinal chemistry Oct 2013 - 7788-803 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm400732v doi
Alanine--analogs & derivatives
Animals
Apoptosis--drug effects
Benzodiazepinones--chemical synthesis
Blotting, Western
Caspase 3--metabolism
Caspase 7--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Crystallography, X-Ray
Female
Heterocyclic Compounds--chemical synthesis
Humans
Inhibitor of Apoptosis Proteins--antagonists & inhibitors
Mice
Mice, Nude
Models, Chemical
Models, Molecular
Molecular Structure
Protein Structure, Tertiary
Ubiquitin-Protein Ligases
X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors
Xenograft Model Antitumor Assays