Effects of the aldehyde dehydrogenase inhibitor disulfiram on the plasma pharmacokinetics, metabolism, and toxicity of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice.

Parise, Robert A

Effects of the aldehyde dehydrogenase inhibitor disulfiram on the plasma pharmacokinetics, metabolism, and toxicity of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice. [electronic resource] - Cancer chemotherapy and pharmacology Dec 2013 - 1195-204 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

1432-0843

10.1007/s00280-013-2296-5 doi


Aldehyde Dehydrogenase--antagonists & inhibitors
Animals
Antineoplastic Agents--pharmacokinetics
Area Under Curve
Benzaldehydes--pharmacokinetics
Chemical and Drug Induced Liver Injury--etiology
Disulfiram--pharmacology
Drug Interactions
Enzyme Inhibitors--pharmacology
Female
Half-Life
Mice