Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug.

Vieira, Md L T

Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug. [electronic resource] - Clinical pharmacology and therapeutics Feb 2014 - 189-98 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

1532-6535

10.1038/clpt.2013.187 doi


Cytochrome P-450 CYP3A Inhibitors
Drug Interactions
Drugs, Investigational--adverse effects
Humans
In Vitro Techniques
Midazolam--blood
Models, Biological
Risk Assessment