Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway.

Chen, Kunlun

Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. [electronic resource] - PloS one 2013 - e72927 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0072927 doi


Animals
Antineoplastic Agents--administration & dosage
Antioxidants--administration & dosage
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Cell Movement--drug effects
Cell Proliferation--drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Flavanones--administration & dosage
Gene Expression Regulation, Neoplastic--drug effects
Humans
Liver Neoplasms--drug therapy
MAP Kinase Signaling System--drug effects
Male
Matrix Metalloproteinase 2--genetics
Matrix Metalloproteinase 9--genetics
Mice
Neoplasm Invasiveness
Neoplasm Metastasis
Tissue Inhibitor of Metalloproteinase-1--genetics
Tissue Inhibitor of Metalloproteinase-2--genetics
Transcription, Genetic
Urokinase-Type Plasminogen Activator--genetics
Xenograft Model Antitumor Assays