Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.
Feiler, Christian
Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency. [electronic resource] - PloS one 2013 - e73123 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
1932-6203
10.1371/journal.pone.0073123 doi
Anti-Bacterial Agents--pharmacology
Biocatalysis--drug effects
Cell Proliferation--drug effects
Clavulanic Acid--pharmacology
Directed Molecular Evolution
Enzyme Stability
Mutation
Mycobacterium smegmatis--drug effects
Mycobacterium tuberculosis--cytology
beta-Lactam Resistance--genetics
beta-Lactamases--chemistry
Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency. [electronic resource] - PloS one 2013 - e73123 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
1932-6203
10.1371/journal.pone.0073123 doi
Anti-Bacterial Agents--pharmacology
Biocatalysis--drug effects
Cell Proliferation--drug effects
Clavulanic Acid--pharmacology
Directed Molecular Evolution
Enzyme Stability
Mutation
Mycobacterium smegmatis--drug effects
Mycobacterium tuberculosis--cytology
beta-Lactam Resistance--genetics
beta-Lactamases--chemistry