Dose-finding design using mixed-effect proportional odds model for longitudinal graded toxicity data in phase I oncology clinical trials.

Doussau, Adélaïde

Dose-finding design using mixed-effect proportional odds model for longitudinal graded toxicity data in phase I oncology clinical trials. [electronic resource] - Statistics in medicine Dec 2013 - 5430-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-0258

10.1002/sim.5960 doi


Adult
Antineoplastic Agents--administration & dosage
Clinical Trials, Phase I as Topic--methods
Computer Simulation
Humans
Likelihood Functions
Longitudinal Studies
Maximum Tolerated Dose
Models, Statistical
Neoplasms--drug therapy
Plant Preparations--administration & dosage
Ribosome Inactivating Proteins, Type 2--administration & dosage
Toxins, Biological--administration & dosage