Leflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivo.

Zhu, Shunqin

Leflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivo. [electronic resource] - PloS one 2013 - e71555 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0071555 doi


Animals
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Dihydroorotate Dehydrogenase
Disease Models, Animal
Down-Regulation--drug effects
Humans
Isoxazoles--pharmacology
Leflunomide
Mice
Mice, SCID
Neuroblastoma--enzymology
Oxidoreductases Acting on CH-CH Group Donors--metabolism
S Phase--drug effects
Xenograft Model Antitumor Assays