Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.

Yu, Xing Xian

Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice. [electronic resource] - PloS one 2013 - e66923 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0066923 doi


Adiposity--drug effects
Animals
Basal Metabolism--drug effects
Bile Acids and Salts--metabolism
Body Weight--drug effects
Caloric Restriction
Diet
Drug Therapy, Combination
Fatty Acids--metabolism
Fatty Liver--blood
Feeding Behavior--drug effects
Fibroblast Growth Factors--blood
Gene Expression Regulation--drug effects
Hepatocytes--drug effects
Insulin--pharmacology
Liver--drug effects
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity--blood
Oligonucleotides, Antisense--pharmacology
Oxidation-Reduction--drug effects
Piperidines--pharmacology
Pyrazoles--pharmacology
Receptor, Cannabinoid, CB1--antagonists & inhibitors
Receptor, Fibroblast Growth Factor, Type 4--genetics
Rimonabant