Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway.

Bai, Tao

Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway. [electronic resource] - International journal of molecular medicine Oct 2013 - 819-26 p. digital

Publication Type: Journal Article

1791-244X

10.3892/ijmm.2013.1464 doi


Anesthetics, Inhalation--adverse effects
Animals
Apoptosis--drug effects
Caspase 3--genetics
Caspase 8--genetics
Caspase 9--genetics
Comet Assay
DNA Damage--drug effects
In Situ Nick-End Labeling
Isoflurane--adverse effects
Mice
Mice, Inbred BALB C
Mitochondria--drug effects
Mitochondrial Membrane Transport Proteins--metabolism
Mitochondrial Permeability Transition Pore
Neurons--cytology
Neuroprotective Agents--pharmacology
Oxidative Stress--drug effects
Proto-Oncogene Proteins c-akt--genetics
Reactive Oxygen Species--metabolism
Resveratrol
Signal Transduction
Stilbenes--pharmacology
Superoxide Dismutase--genetics