The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76.

Smith, Xin

The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76. [electronic resource] - Science signaling Jul 2013 - ra65 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1937-9145

10.1126/scisignal.2004018 doi


Actins--metabolism
Adaptor Proteins, Signal Transducing--metabolism
Animals
CD3 Complex--metabolism
Cell Proliferation
Chemokine CXCL12--metabolism
Cluster Analysis
Enzyme-Linked Immunosorbent Assay
Gene Expression
Humans
Jurkat Cells
Mice
Microscopy, Fluorescence
Mutation
Phosphoproteins--metabolism
Phosphorylation
Receptors, CXCR4--metabolism
Signal Transduction
Spleen--cytology
T-Lymphocytes--cytology
Tyrosine--chemistry
ZAP-70 Protein-Tyrosine Kinase--metabolism