Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.

Hen, Naama

Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus. [electronic resource] - Journal of medicinal chemistry Aug 2013 - 6467-77 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm4007565 doi


Acetamides--pharmacokinetics
Amides
Animals
Anticonvulsants--pharmacokinetics
Disease Models, Animal
Rats
Soman--antagonists & inhibitors
Status Epilepticus--drug therapy
Stereoisomerism
Teratogens--toxicity
Valproic Acid--pharmacokinetics