High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: an example with epicardial inotropic drug delivery.

Maslov, Mikhail Y

High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: an example with epicardial inotropic drug delivery. [electronic resource] - Journal of controlled release : official journal of the Controlled Release Society Oct 2013 - 201-7 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1873-4995

10.1016/j.jconrel.2013.06.038 doi


Alginates--chemistry
Animals
Calcium--chemistry
Cardiotonic Agents--administration & dosage
Cyclic AMP--metabolism
Delayed-Action Preparations--administration & dosage
Drug Delivery Systems
Epinephrine--administration & dosage
Glucuronic Acid--chemistry
Heart Ventricles--metabolism
Hexuronic Acids--chemistry
Hydrogels
Infusions, Intravenous
Male
Myocardial Contraction--drug effects
Pericardium--metabolism
Rats
Rats, Sprague-Dawley