Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion.

Tanaka, Hirotsugu

Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. [electronic resource] - The Journal of pharmacology and experimental therapeutics Sep 2013 - 443-52 p. digital

Publication Type: Journal Article

1521-0103

10.1124/jpet.113.206466 doi


Animals
Biphenyl Compounds--pharmacology
Blood Glucose--metabolism
CHO Cells
Calcium--metabolism
Cricetinae
Cricetulus
Diabetes Mellitus--genetics
Glucose--metabolism
Glucose Clamp Technique
Glucose Tolerance Test
Insulin--metabolism
Male
Mice
Mice, Inbred ICR
Mice, Obese
Oxadiazoles--pharmacology
PPAR gamma--metabolism
Rats
Rats, Zucker
Receptors, G-Protein-Coupled--agonists
Transcriptional Activation--drug effects