Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain.

Labuz, Dominika

Stronger antinociceptive efficacy of opioids at the injured nerve trunk than at its peripheral terminals in neuropathic pain. [electronic resource] - The Journal of pharmacology and experimental therapeutics Sep 2013 - 535-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0103

10.1124/jpet.113.205344 doi


3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer--pharmacology
Analgesics, Opioid--administration & dosage
Animals
Behavior, Animal--drug effects
Constriction, Pathologic--pathology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)---pharmacology
Enkephalin, D-Penicillamine (2,5)---pharmacology
Foot--innervation
Hot Temperature
Hyperalgesia--drug therapy
Male
Mice
Mice, Inbred C57BL
Nerve Endings--drug effects
Neuralgia--drug therapy
Pain Measurement--drug effects
Peripheral Nerve Injuries--drug therapy
Peripheral Nerves--drug effects
Physical Stimulation
Receptors, Opioid--agonists