Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.

Zhu, Yuyan

Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression. [electronic resource] - The Journal of clinical investigation Jul 2013 - 2935-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1558-8238

10.1172/JCI65988 doi


Active Transport, Cell Nucleus
Animals
Apoptosis
Caspase 2--metabolism
Caspase 3--metabolism
Cysteine Endopeptidases--metabolism
E2F1 Transcription Factor--metabolism
Feedback, Physiological
Gene Expression
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasm Regression, Spontaneous
Nerve Growth Factor--physiology
Nerve Growth Factors--metabolism
Netrin-1
Neuroblastoma--metabolism
PC12 Cells
Prognosis
Proteolysis
Rats
Receptors, Cell Surface--genetics
Transcriptional Activation
Tumor Suppressor Protein p53--metabolism
Tumor Suppressor Proteins--metabolism
Up-Regulation