Network quantification of EGFR signaling unveils potential for targeted combination therapy.

Klinger, Bertram

Network quantification of EGFR signaling unveils potential for targeted combination therapy. [electronic resource] - Molecular systems biology 2013 - 673 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1744-4292

10.1038/msb.2013.29 doi


Animals
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Colorectal Neoplasms--drug therapy
Drug Screening Assays, Antitumor
Drug Therapy, Combination
ErbB Receptors--genetics
Extracellular Signal-Regulated MAP Kinases--genetics
Gene Expression Regulation, Neoplastic--drug effects
Humans
Mice
Mice, Nude
Models, Genetic
Phosphatidylinositol 3-Kinases--genetics
Protein Interaction Maps--drug effects
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins B-raf--genetics
Proto-Oncogene Proteins c-akt--genetics
Signal Transduction--drug effects
Transplantation, Heterologous
Tumor Burden--drug effects
ras Proteins--genetics