Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Ardecky, Robert J
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. [electronic resource] - Bioorganic & medicinal chemistry letters Jul 2013 - 4253-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1464-3405
10.1016/j.bmcl.2013.04.096 doi
Binding Sites
Biomimetic Materials--chemical synthesis
Cell Line, Tumor
Cell Survival
Drug Design
Drug Resistance, Neoplasm--drug effects
Humans
Molecular Docking Simulation
Oligopeptides--chemical synthesis
Protein Binding
Protein Structure, Tertiary
Structure-Activity Relationship
TNF-Related Apoptosis-Inducing Ligand--pharmacology
X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. [electronic resource] - Bioorganic & medicinal chemistry letters Jul 2013 - 4253-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1464-3405
10.1016/j.bmcl.2013.04.096 doi
Binding Sites
Biomimetic Materials--chemical synthesis
Cell Line, Tumor
Cell Survival
Drug Design
Drug Resistance, Neoplasm--drug effects
Humans
Molecular Docking Simulation
Oligopeptides--chemical synthesis
Protein Binding
Protein Structure, Tertiary
Structure-Activity Relationship
TNF-Related Apoptosis-Inducing Ligand--pharmacology
X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors