The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab.

van Mierlo, Geertje J D

The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab. [electronic resource] - Journal of immunotoxicology - 62-71 p. digital

Publication Type: Journal Article

1547-6901

10.3109/1547691X.2013.796023 doi


Adalimumab
Animals
Antibodies, Monoclonal--administration & dosage
Antibodies, Monoclonal, Humanized--administration & dosage
Antibody Formation--drug effects
Drug Evaluation, Preclinical
Feasibility Studies
Female
Humans
Infliximab
Injections, Subcutaneous
Metabolic Clearance Rate
Swine
Swine, Miniature
Tumor Necrosis Factor-alpha--metabolism