N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.

Lovell, Kimberly M

N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. [electronic resource] - Bioorganic & medicinal chemistry letters Jul 2013 - 3713-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3405

10.1016/j.bmcl.2013.05.020 doi


Allosteric Regulation--drug effects
Animals
Central Nervous System--drug effects
Dose-Response Relationship, Drug
Molecular Structure
Piperazines--chemical synthesis
Rats
Receptors, Metabotropic Glutamate--antagonists & inhibitors
Structure-Activity Relationship