The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice.

Liu, Zhen

The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice. [electronic resource] - British journal of pharmacology Aug 2013 - 1795-809 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.12246 doi


Animals
Aorta--metabolism
Apolipoproteins E
Atherosclerosis--chemically induced
Cells, Cultured
Cholesterol--metabolism
Diet, High-Fat
Down-Regulation
Endothelium, Vascular--metabolism
Female
Foam Cells--drug effects
Humans
I-kappa B Proteins
Intercellular Adhesion Molecule-1--metabolism
Interleukin-6--metabolism
Macrophages--drug effects
Male
Mice
Morpholines--pharmacology
NF-KappaB Inhibitor alpha
NF-kappa B--metabolism
Nitric Oxide Synthase Type II
Organothiophosphorus Compounds--pharmacology
Oxidative Stress--drug effects
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation--drug effects
Scavenger Receptors, Class E--drug effects
Superoxides--metabolism
Tumor Necrosis Factor-alpha--metabolism
Vascular Cell Adhesion Molecule-1--metabolism