Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Patterson, Andrew D

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. [electronic resource] - Chemical research in toxicology Jul 2013 - 1088-96 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

1520-5010

10.1021/tx4001013 doi


Acetaminophen--toxicity
Animals
Chemical and Drug Induced Liver Injury--metabolism
Glutathione--analysis
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
NF-E2-Related Factor 2--genetics
Thioredoxin Reductase 1--antagonists & inhibitors