HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.

DeLucia, Maria

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. [electronic resource] - The Journal of biological chemistry Jun 2013 - 19116-26 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M113.469007 doi


Amino Acid Sequence
Animals
Catalysis
Cross-Linking Reagents--pharmacology
HEK293 Cells
HIV-2--metabolism
Humans
Macaca mulatta
Molecular Sequence Data
Monomeric GTP-Binding Proteins--metabolism
Proteasome Endopeptidase Complex--metabolism
Protein Binding
Protein Structure, Tertiary
SAM Domain and HD Domain-Containing Protein 1
Sequence Homology, Amino Acid
Simian Immunodeficiency Virus--metabolism
Surface Plasmon Resonance
Ubiquitin--metabolism
Viral Regulatory and Accessory Proteins--metabolism
Virulence Factors--metabolism