Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.

Anderson, Matt S

Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib. [electronic resource] - Journal of clinical pharmacology Jul 2013 - 746-52 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1552-4604

10.1002/jcph.97 doi


Adult
Area Under Curve
Cytochrome P-450 CYP3A--metabolism
Drug Interactions
Female
Humans
Inactivation, Metabolic
Liver-Specific Organic Anion Transporter 1
Male
Middle Aged
Organic Anion Transporters--antagonists & inhibitors
Organic Anion Transporters, Sodium-Independent--antagonists & inhibitors
Oxazolidinones--administration & dosage
Rifampin--adverse effects
Solute Carrier Organic Anion Transporter Family Member 1B3
Young Adult