Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.

Hudecek, Michael

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Jun 2013 - 3153-64 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1557-3265

10.1158/1078-0432.CCR-13-0330 doi


Animals
Cell Line, Tumor
Humans
Mice
Neoplasms--immunology
Protein Structure, Tertiary
Receptor Tyrosine Kinase-like Orphan Receptors--genetics
Receptors, Antigen, T-Cell--genetics
Signal Transduction
Single-Chain Antibodies--genetics
T-Lymphocytes--immunology
Xenograft Model Antitumor Assays