Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

Abdul-Hay, Samer O

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. [electronic resource] - Journal of medicinal chemistry Mar 2013 - 2246-55 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm301280p doi


Drug Design
Enzyme Inhibitors--chemical synthesis
Humans
Hydroxamic Acids--chemical synthesis
Insulysin--antagonists & inhibitors
Molecular Docking Simulation
Peptides--chemistry
Protein Conformation
Stereoisomerism
Substrate Specificity