Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.

Arora, Karunesh

Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase. [electronic resource] - Topics in current chemistry 2013 - 165-87 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review

0340-1022

10.1007/128_2012_408 doi


Catalysis
Hydrogen--chemistry
Mutation
Protein Conformation
Structure-Activity Relationship
Tetrahydrofolate Dehydrogenase--chemistry