Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate.
Barbara, Joanna E
Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2013 - 1012-22 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.113.051151 doi
Chromatography, Liquid
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inhibitors
Enzyme Inhibitors--pharmacology
Humans
Lapatinib
Mass Spectrometry
Microsomes, Liver--metabolism
Nitrogen Oxides--metabolism
Oximes--metabolism
Quinazolines--pharmacology
Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2013 - 1012-22 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.113.051151 doi
Chromatography, Liquid
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inhibitors
Enzyme Inhibitors--pharmacology
Humans
Lapatinib
Mass Spectrometry
Microsomes, Liver--metabolism
Nitrogen Oxides--metabolism
Oximes--metabolism
Quinazolines--pharmacology