Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity.

Artursson, Elisabet

Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. [electronic resource] - Biochemical pharmacology May 2013 - 1389-97 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-2968

10.1016/j.bcp.2013.01.016 doi


Acetylcholinesterase--chemistry
Animals
Antidotes--chemistry
Catalytic Domain
Chemical Warfare Agents--chemistry
Cholinesterase Inhibitors--chemistry
Crystallography, X-Ray
Humans
Mice
Models, Molecular
Organophosphates--chemistry
Organophosphorus Compounds--chemistry
Organothiophosphorus Compounds--chemistry
Oximes--chemistry
Protein Conformation
Pyridinium Compounds--chemistry
Spectrometry, Fluorescence
Substrate Specificity