The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity.

Touil, Yasmine

The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity. [electronic resource] - Stem cells (Dayton, Ohio) Apr 2013 - 641-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1549-4918

10.1002/stem.1333 doi


ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics
Cell Cycle--drug effects
Cell Line, Tumor
Chromones--pharmacology
Cyclin D1--genetics
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--genetics
Immunohistochemistry
Melanoma--metabolism
Morpholines--pharmacology
Neoplastic Stem Cells--drug effects
Octamer Transcription Factor-3--genetics
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Rhodamine 123--pharmacology
Signal Transduction--drug effects
Tumor Cells, Cultured