BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells.
He, Dan
BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. [electronic resource] - PloS one 2013 - e54181 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0054181 doi
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Blotting, Western
Cell Line, Tumor
Cell Survival--drug effects
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Drug Synergism
Gene Expression Regulation, Neoplastic
HEK293 Cells
HL-60 Cells
Humans
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Naphthalenes--pharmacology
Neoplasms--drug therapy
Paclitaxel--pharmacology
Protein Kinase Inhibitors--pharmacology
Pyrazoles--pharmacology
RNA Interference
Reverse Transcriptase Polymerase Chain Reaction
Xenograft Model Antitumor Assays
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors
BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. [electronic resource] - PloS one 2013 - e54181 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0054181 doi
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Blotting, Western
Cell Line, Tumor
Cell Survival--drug effects
Drug Resistance, Multiple--drug effects
Drug Resistance, Neoplasm--drug effects
Drug Synergism
Gene Expression Regulation, Neoplastic
HEK293 Cells
HL-60 Cells
Humans
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Naphthalenes--pharmacology
Neoplasms--drug therapy
Paclitaxel--pharmacology
Protein Kinase Inhibitors--pharmacology
Pyrazoles--pharmacology
RNA Interference
Reverse Transcriptase Polymerase Chain Reaction
Xenograft Model Antitumor Assays
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors