The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells.
D'Assoro, A B
The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. [electronic resource] - Oncogene Jan 2014 - 599-610 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2012.628 doi
Active Transport, Cell Nucleus
Animals
Aurora Kinase A--antagonists & inhibitors
Breast Neoplasms--enzymology
CD24 Antigen--genetics
Cell Line, Tumor
Cell Movement--genetics
Epithelial-Mesenchymal Transition--genetics
Estrogen Receptor alpha--biosynthesis
Female
Gene Expression Regulation, Neoplastic
Humans
MAP Kinase Signaling System--genetics
MCF-7 Cells
Mice
Mice, Nude
Neoplasm Metastasis
Neoplasm Transplantation
Neoplastic Stem Cells--cytology
Phosphorylation--genetics
Proto-Oncogene Proteins c-raf--metabolism
RNA Interference
RNA, Small Interfering
Receptor, ErbB-2--biosynthesis
SOXB1 Transcription Factors--genetics
Smad5 Protein--metabolism
Xenograft Model Antitumor Assays
The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. [electronic resource] - Oncogene Jan 2014 - 599-610 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2012.628 doi
Active Transport, Cell Nucleus
Animals
Aurora Kinase A--antagonists & inhibitors
Breast Neoplasms--enzymology
CD24 Antigen--genetics
Cell Line, Tumor
Cell Movement--genetics
Epithelial-Mesenchymal Transition--genetics
Estrogen Receptor alpha--biosynthesis
Female
Gene Expression Regulation, Neoplastic
Humans
MAP Kinase Signaling System--genetics
MCF-7 Cells
Mice
Mice, Nude
Neoplasm Metastasis
Neoplasm Transplantation
Neoplastic Stem Cells--cytology
Phosphorylation--genetics
Proto-Oncogene Proteins c-raf--metabolism
RNA Interference
RNA, Small Interfering
Receptor, ErbB-2--biosynthesis
SOXB1 Transcription Factors--genetics
Smad5 Protein--metabolism
Xenograft Model Antitumor Assays